Trademarked, the BRODERICK PROBE®, the tiny nanoprobe was created by a tiny but mighty five-foot girl, Dr. Patricia Ann Broderick, PhD. The name was to honor her father, Patrick Broderick, Patricia felt a strong desire to name the nanoprobe sensor after her father as her father was killed and taken from her in a shocking oxyacetylene torch welding accident on the Christmas Eve when Patricia had just turned the age of seven. The abandonment that Patricia feels every Christmas Eve is formidable and the complexity of the brain always propelled her to elucidate how the brain works. What happened to her father?
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Patricia is a first-generation Irish American. She is the child of Patrick Broderick and Margaret Daly, immigrants to America from County Clare, Ireland and Bantry Bay, County Cork, Ireland. Her family took root in the Throggs Neck Section in the Bronx, moved to Philadelphia and then back to the Bronx when Patricia was five. This time it was the South Bronx, a Catholic, blue-collar, poor and happy Irish neighborhood where everyone was family.
The environment was supporting and loving which helped the family to be strong in the face of such horror. Patricia was always bright and extremely perceptive. Quietly, she helped all her peers at every level to study and pass exams smoothly with the manner in which she taught. Everyone waited for Patricia to synthesize the course, no matter what the course was, and break it down into understanding. To this day, Patricia makes complexity into simplicity and she is affectionately called a “super power brain”.
The nanoprobe just may make it to the Nobel Prize despite her humble beginnings in her happy, yet poor Irish family in a tenement neighborhood in the South Bronx, New York, NY, USA. So many people of all walks in life believe that she will make it in honor of her father and her courageous mother, her family and dear colleagues. Patricia has spent a lifetime figuring out how the brain works to make the world better. Humble herself, she asks to this day for so little financial support and seeks less. It is said that her work is maximal on such minimal requests.
Patricia began her innovative spectroscopy work at St John’s University College of Arts and Sciences and continued on to the Einstein College of Medicine where she made dramatic advances in sensing the brain using electrochemistry. With her background in the fields of physiology, pharmacology and the neurosciences, Patricia has made critical advances in the sensing field of electrochemistry and its application to the field of nanotechnology, an imaging technology, Neuromolecular Imaging. She then continued to Cornell University School of Medicine and currently serves as a full Medical Professor at the City University of New York School of Medicine at the City College of New York.
Dr. Broderick, both herself and her work embody the phraseology from the Nobel Peace Presentation Speech, 1977 wherein the Irish spirit of justice wins the award. The Irish courageous spirit rails against indignity and promotes the cause of human dignity instead. Patricia’s philosophy for her entire life is to promote human dignity in her teaching and her research.
But, what Patricia has done that virtually no one else has done is to promote animal dignity along with human dignity. She has changed the way to study animals by using her nanoprobe and her Neuromolecular Imaging nanotechnology.
Her philosophy is that all are created equally and all should be treated equally and with the highest respect. She believes that people in power should have the grace of office as described in theology.
“Power of authority should not be used as power of abuse.”
Rational behavior in the academe and everywhere needs to be honored. One level need not destroy another because of jealousy or ill will. Her students and her research technicians feel her philosophy of equal power based on resolute and solid direction toward the good of the institution and the person. Her philosophy is embedded in the following phrase; it is paraphrased as it regards the Irish American spirit in Patricia herself and it relates and transfers to all people of nationality, age and each and every gender.
Patricia is an individual who holds the deep and firmly rooted conviction that the ordinary man and woman is capable of making a meaningful contribution to peace. The peace that Patricia has made is in the field of science and medicine where she is courageous in promoting the dignity of animals as well as humans. Patricia believes in working diligently and being fair and just in her teaching and research and everyday life.
Indeed, Dr. Broderick has pioneered nanotechnology to be fair to animals wherein she has changed the science and medicine community away from the after death, post-mortem work into LIVE imaging. In fact, her work translates to the clinic, where she is the first, with her team, to change the way that physicians think about science and bedside medicine.
One part of her work that may well deserve the Nobel Award is her translational work for the epilepsy patient to bring about Personalized LIVE Medicine. The nanoprobe is the first to see the neurochemistry of the human epilepsy patient brain during epilepsy surgery exactly in the operating room side by side with the neurosurgeon and in fact, collegially directing the neurosurgeon in the mechanics of the BRODERICK PROBE® sensing nanoprobe.
The nanoprobe is the first of its kind. It is a polymer made of non-toxic biocompatible scientifically advanced formulas designed by Dr. Broderick. This probe is actually a series of sensors/nanoprobes, each of which is smaller than one human hair, it has been tested for bacterial infection by the microbiologists at NYU Langone and the results show that it does not promote bacterial formation. The tiny probe does not cause scarring as this has been tested and the report by the pathologist at NYU Langone Medical Center is published in the report from the clinical trial (1).
From what anyone can see is that certainly a considerable amount of Insight and engineering aplomb has gone into the translation of the sensor from lab to clinic. It is extraordinary, original and the first of its kind. Although the work and Patricia’s dynamic personality are loved by many around the globe, there are the misanthrope’s.
Her break-through and cutting-edge research is sought after and she personally lays prey to the tyranny and terror that does exist when one’s genius is original and leans toward being lucrative. Yes, her professional life is productive and her work is appreciated globally, however, there are times that this particular injustice of jealousy even from power besets her due to her genius in the work of the tiny probe and due to her principles in engendering dignity to animal research and dignity for all, no matter what level of power.
(1) Broderick PA et al., (2009) A clinical trial of an advanced diagnostic biomedical device for epilepsy patients. J. Long-Term Effects of Medical Implants Vol. 18, June 1.
Patricia continues to be strong in her belief in honesty and justice in science and medicine in the academe despite the suffering that is put upon her for promoting animal dignity as well as human dignity and for devoting her life to making and sharing the tiniest sensor in the world capable of LIVE studies in humans and animals.
It is true that many are willing to die for a cause and some are willing to live a lifetime fighting for a cause. Patricia is willing to suffer, live and die for the cause.
With this philosophy in mind, Patricia has gone on to change the face of science and medicine because her biomedical sensors link to the brain to see inside the animal and the human brain. In fact, the nanoprobes are the smallest biomedical sensors for LIVE Imaging in the world and they have gained tremendous recognition in the academic as well as in the medical press.
What Patricia has done differently from the majority of the professional scientists is this, the nanoprobe is available to and for the lay person. She has made it a product and it is an affordable product. Yes, the sensors reach the lay person in particular in the inventor’s quest to share medicine and science with all people around the globe.
The sensors reach undergraduate students in the City College of New York. The Professor teaches a novel Interdisciplinary course in the study of the Neurobiology of Drug Abuse. Her 200 interested and interesting students meet every week, each semester and she has taught the medical students, who are now, the practicing physicians of the world. She has taught the Physician Assistants and served as a former director. The students enjoy her style of creative techniques in teaching. The students report that Professor Broderick, a full and tenured Medical Professor making complex material into understandable meaning for life’s tasks.
Her enlightening research reaches the health magazines for the lay person. A person can pick up the knowledge at the newsstand as Patricia is published in Preferred Health Magazine. She is known for her in-depth contribution to the Covid 19 pandemic. She was the first to publish her deeply thought out empirical and theoretical discovery that the Covid 19 affects the brain of the healthy and the unhealthy.
The Broderick laboratory has configured the algorithms for the LIVE cytokine mobility into the hippocampal neurons to damage memory. Adaptation and stress mechanisms as these relate to suicide, depression, schizophrenia and bipolar affect represent just part of her contributions.
Brain reward and Temporal Synchrony are everyday vocabulary for the world to understand as coming from her work!
Dr. Broderick is a force to bring the new science and medicine to the lay world for understanding.
Along these lines then, Dr. Broderick is host of the syndicated and global BBM radio shows, The Easysense Show is still available and her TV Eazysense Show launches in November, 2022; her new generation nanoprobe is the focus. In fact, that is not all. The work and she are no stranger at all to the airways.
Close up TV radio with Doug Llewelyn and close up TV radio with Jim Masters, the Dr. Robi Ludwig Show, the Jill Nicolini show, The Donna Drake Show are on YouTube. She is booked for the Melissa Billy Clark show on November 17th.
Patricia’s major discovery is the BRODERICK PROBE®. What the series of nanoprobe sensors can do is awesome! The advanced materials and preclinical and clinical applications are considered by many as Nobel material. Patricia has promoted the concept that the brain itself is an electrochemical device.
“The brain is electrochemical and molecular; it matches the BRODERICK PROBE® electrochemical and molecular brain matrix.”
The nanoprobe actually meets the brain, attaches to it and then leaves the brain intact and whole. There is no other technology or nanotechnology that can do it. The nanoprobe is not one probe; it is a series of probes, sensing devices, sensors that see inside the brain whatever you need, wherever you need it.
The nanoprobe sees chemicals and neurotransmitters inside the brain. This nanotechnology is ready for market manufacturers and with the help of partners, for financial funding by sponsors, investors and philanthropists, a response in shares in the company Eazysense Nanotechnologies Inc. is in order.
The BRODERICK PROBE® sensors relate to several formulations of unique, patented, and trademarked miniature carbon sensors comprising a series of compounds which include, among others, classes of molecules in the biochemical categories of lipid, glycolipid, lipoprotein, saturated and unsaturated fatty acid.
These inventions are able to detect electrochemical signals in the living animal brain and the human brain for a vast number of neurotransmitters, neuromodulators, and metabolites, including neuropeptides.
Diagnosis of Tumors
The MRI cannot see white matter. When the surgeon is tracking the tumor, they can see the tumor in the gray matter. Then, suddenly, the tumor is lost to the eye of the surgeon and to the MRI as white matter is hidden. Water is in the way. Diffusion tensor can help, but still MRI is needed first and with contrast media that causes allergies. Enter Neuromolecular Imaging (NMI) to see the white matter. The nanoprobe can see the white matter in sub seconds. The BRODERICK PROBE® has shown, for the first time, a distinct difference, in tissue resected from epilepsy patients, between hippocampal white versus gray matter.
The Non-Invasive Optical Nanoprobe-Electrons to Photons
Using Neuromolecular Imaging, the BRODERICK PROBE® is patented preclinically and clinically as carbon and protein-based semiconductor nanoprobes with integrated interfacial surface algorithms for programming online unique neurobehavior. Biosensing recognizable neuromolecular elements in anion and cation ranges of neurotransmitters LIVE, while neurobehavior is imaged online, further advances material science and dramatically moves discoveries in neurotransmission forward.
The disclosed embodiments of the non- invasive patent by Broderick relate to a miniature photosensitive, electroactive polymer sensing device that operates by converting photonic energy into electrical and electrochemical energy that generates a photocurrent in the brain without opening the brain. The output is provided in units of voltage. Laser diodes then enable the electrochemical waveform to be seen as an electrochemical image in color separated into specific spectral frequencies. Thus, the photocurrent provides an image of neurochemicals in real time, noninvasively and/or minimally invasively. The embodiments provide a photoelectrochemical conductance device for nanodiagnostics, nanotherapies, and nanotheranostics. These embodiments are directly applicable to specific neurodegenerative and psychiatric disorders in humans and animals including, but not limited to, diseases of the motor and sensory systems in the brain, body, and blood.
We are poised to read empirically derived signal processing-based algorithms on the BRODERICK PROBE® from multiple interconnected sites in brain, upper and lower limbs, these programmed sensing neuromolecular devices further equip the paralyzed person for agile mobility. The epidural spinal cord patient will benefit. The Parkinson patient will benefit. Exquisite detail in information processing is essential and selective frequency of neurotransmission plus afferent or efferent signal dynamics from one neuroanatomic site to another is paramount to deciphering the significance of neurotransmission in concert with mobility. Along with pure carbon polymers, the BRODERICK PROBE® fiber optical based programmable vector biosensing devices enable recognizable molecular elements for entropy in artificial intelligence (AI). The dementias, Alzheimer, Parkinson, epilepsy, stroke and brain reward circuits of orgasm and the like suit the tiny probes all the more.
Patricia is the first to sense the brain as an expert in both fields. There is no one else who has accomplished this feat.
In one of Dr. Broderick’s recent books, an Imaging Textbook that is indeed a monograph, the evolution of In Vivo Electrochemistry into Neuromolecular Imaging into Non- Invasive Voltaic Photonics: LIVE IMAGING, her inventions that make her work original and far above the fray, is told in detail. The book is in press, on course this year, from Singapore, Jenny Stanford Publishing Pte Ltd. For a scientist to, in fact, write a monograph on how she discerns her lifetime work is most unusual and this is an understatement. These major discoveries are delineated by the master herself and precise patented protocols for her imaging techniques are told with unique delivery. It is amazing how she intersperces her personal life into the professional as she writes in her book the exact patented protocols for her discoveries. She tells of her interrelationships, how her dedication, wisdom and sense of humor propelled her through her path that was less chosen as in the poetry of Robert Frost.
In her book, she courageously takes on the fight over electrocatalysis!
The problem of electrocatalysis, that is, the mix-up between the detection of dopamine (DA) and ascorbic acid (AA) electrochemically, was indeed a problem. This problem was the very bane of the existence of the neuroscientist who wished to be the “one” to be the expert “in vivo electrochemist” and vice versa. But these scientists, neuroscientist or electrochemist, apparently could not do it! Each and every scientist involved began to author manuscripts in which the authors could detect ascorbic acid or dopamine but none could detect both molecules separately and clearly. What could be done? Someone had to do it! Then, Broderick stepped up to the plate, so to speak. What did Broderick do? Broderick accomplished the necessary! What was accomplished between 1983 and 2008 was the saving grace for in vivo electrochemistry for growth in the electrochemistry field in vivo and preparation for the advent of neuromolecular imaging and cerebral polymeric, photosensitive, photoelectric and piezoelectric live imaging. The future of in vivo electrochemistry in spectral analysis now has its place, humbly, via the contribution of the neuroscientist electrochemist, Broderick and her team.
Patricia’s legacy:
Patricia is the first to sense the brain as an expert in both fields. There is no one else who has accomplished this feat.
Patricia’s advancements to science and medicine continue. Dr. Broderick is honored once again as the sole editor of the second edition of her successful Humana Press book, Bioimaging in Neurodegeneration; her next new book is entitled, Biomedical Imaging in Neurodegeneration, under contract with the prestigious Springer Nature Publishing Group.
Conclusion
There is one unmistakable chord throughout her closely intertwined work and life that she has a true genius in uncovering the truth. Her brilliant childlike innocent approach to discernment is enchanting and her passion envelops one’s very soul. Perhaps, she will humbly meet with the Nobel Prize! Indeed, there are peaceful clusters of scientists around the world discussing the desire that a woman scientist should be one of the recipients. Perhaps she has even been nominated already!
Paragraph from Chapter 3 of her book, Neuroimaging Sensing Biochemistry in the Brain,
Nathaniel Hawthorne wrote: “Time flies over us, but leaves its shadow behind” Twenty-five years—one quarter of one century, a century of shadows, of joyful shadows, of sorrowful shadows, each and every nanosecond remembered. Each and every scientist, colleague, family, friend and acquaintance, remembered. Each and every student remembered. Each and every discovery remembered. Each and every kind greeting, encouragement and each and every hurtful word and action remembered. Each and every supporter and each and every detractor and/demoralizer, all limbic-related in emotion and cortically analytically ordered to help Patricia’s mind/brain/soul grow in depth, mentally and spiritually, is deeply remembered. William Shakespeare wrote: “Time is very slow for those who wait, very fast for those who are scared, very long for those who lament, very short for those who celebrate”—But for those who love, time is eternal. For Patricia, time is eternal.
Eric Mastrota is a Contributing Editor at The National Digest based in New York. A graduate of SUNY New Paltz, he reports on world news, culture, and lifestyle. You can reach him at eric.mastrota@thenationaldigest.com.
