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Arizona Resident Dies from Rare Case of Pneumonic Plague

A resident of Coconino County, Arizona, has died from pneumonic plague, the first fatal case reported in the area since 2007. While local officials are stressing that the death appears unrelated to a recent and mysterious die-off of prairie dogs near Flagstaff, both incidents are drawing renewed attention to a disease more often associated with medieval history than modern life.

The individual, whose identity and demographic details have not been disclosed, reportedly arrived at Flagstaff Medical Center’s emergency department and died that same day, according to local health officials.

A spokesperson for Northern Arizona Healthcare (NAH) confirmed that the individual died from a “severe lung infection caused by the Yersinia pestis bacterium” and that “despite appropriate initial management and attempts to provide life-saving resuscitation, the patient did not recover.”

“NAH would like to remind anyone who suspects they are ill with a contagious disease to contact their health care provider. If their illness is severe, they should go to the emergency Department and immediately ask for a mask to help prevent the spread of disease while they access timely and important care.”

Coconino County encompasses a swath of northern Arizona, including part of Grand Canyon National Park. While human cases of plague are extremely rare in the U.S., the bacterium Yersinia pestis, the culprit behind the Black Death outbreak in the 1340s, still lingers in parts of the American Southwest.

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The Centers for Disease Control and Prevention (CDC) reports roughly seven human plague cases annually across the country, with the vast majority occurring in rural areas of western states. Since 2000, only 15 plague-related deaths have been recorded nationwide.

This latest case involves pneumonic plague, the rarest and most virulent form of the disease, which attacks the lungs and can spread through respiratory droplets. In contrast, the more common bubonic plague is typically transmitted via flea bites and affects the lymphatic system.

Bubonic plague may still lead to painful, swollen lymph nodes known as buboes, but it can be easily cured if treated with antibiotics early. Pneumonic plague can trigger symptoms such as fever, fatigue, chills, and severe pneumonia within a week of exposure.

Although the patient’s case is believed to be isolated, county officials have launched an investigation into a concurrent spike in prairie dog deaths northeast of Flagstaff. Trish Lees, a communications manager for Coconino County, told the Arizona Republic that the total number of deceased prairie dogs is still being assessed.

Despite the timing, health authorities have stated that as of right now, there is no evidence linking the recent death to the prairie dog die-off. However, the county has issued precautionary guidelines for residents and visitors to reduce potential exposure to Yersinia pestis.

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These include avoiding sick or dead animals, steering clear of rodent burrows when camping, refraining from sleeping directly on the ground, and using insect repellents. Tucking pants into socks is also recommended for extra protection against fleas.

“Report prairie dog die-offs. Prairie dogs are highly susceptible to plague but are not considered a long-term reservoir of the disease. They typically die off quickly after infection, making them an indicator species for plague presence. Active prairie dog colonies are not harmful, but a sudden reduction/die-off in prairie dog colonies may indicate the presence of disease.”

While Yersinia pestis is known to persist in rodent populations, particularly in the Southwest, human infections remain exceedingly rare and person-to-person transmission of pneumonic plague is even rarer. In fact, the last confirmed case of such transmission in the U.S. occurred in Los Angeles more than a century ago, in 1924.

Arizona itself has reported only seven plague cases since 2006. Yet the region is no stranger to other zoonotic diseases, including hantavirus, rabies, and West Nile virus, which are considered endemic to the area.

“Our hearts go out to the family and friends of the deceased,” said Coconino County Board of Supervisors Chair Patrice Horstman. “We are keeping them in our thoughts during this difficult time. Out of respect for the family, no additional information about the death will be released.”

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Genes That Helped People Survive the Plague Linked to Autoimmune Disorders in Descendants

Scientists have discovered that the same genetic characteristics that helped people survive the Black Death more than 700 years ago are now linked to an elevated risk of developing certain autoimmune disorders.

Using the DNA of victims and survivors of the Black Death from the 14th century, scientists have discovered that Europeans with a variation of the gene called ERAP2 had a substantially better chance of surviving the disease. The mutations provided protection against the Black Death pathogen Yersinia pestis, which went on to kill off nearly half of Europe’s population.

These results, published in the Journal “Nature,” provide insight into how the Black Death influenced the development of immunity genes like ERAP2 and laid the groundwork for how some people react to disease today. For instance, inheritors of the gene have a higher risk for autoimmune diseases such as Crohn’s disease and arthritis.

Luis Barreiro, professor of genetic medicine at the University of Chicago Medical Center and co-author of the study, believes this study provides new insight into the true evolutionary impact of the plague.

“This is, to my knowledge, the first demonstration that indeed, the Black Death was an important selective pressure to the evolution of the human immune system.”

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The study was carried out on more than 500 ancient DNA samples collected from the teeth of people who had died before, during or after the plague. Some samples were taken from skeletons buried in London’s East Smithfield plague pits. According to Barreiro, the pits were used for mass burials in 1348 and 1349 when people were dying so quickly that the city’s cemeteries were running out of space.

“So the king [Edward III], at the time, bought this piece of land and started digging it. There’s basically layers and layers of bodies one on top of each other.”

Samples that contained two copies of the ERAP2 gene indicated an ability to produce functional proteins, which helped the immune system to recognize an infection. The variant also helped immune cells neutralize the virus more efficiently, making the person 40% more likely to survive the plague than their peers. However, the mutations enhanced the body’s inflammatory response, making people more susceptible to autoimmune disorders.

Hendrik Poinar, professor of anthropology at McMaster University in Canada and co-senior author of the study, said the study showed the ability of pandemics to alter genome sequences in the long-term without being detected in modern populations.

“These genes are under balancing selection – what provided tremendous protection during hundreds of years of plague epidemics has turned out to be autoimmune-related now. A hyperactive immune system may have been great in the past, but in the environment today, it might not be as helpful.”

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Evolutionary biologist David Enard from the University of Arizona said the speed of the adaptation over just a few decades had other implications. The 40% survival advantage the variant bestowed is the most significant evolutionary advantage recorded in humans.

“The evolution is faster and stronger than anything we’ve seen before in the human genome. It’s really a big deal. It shows what’s possible [for humans], in terms of adaptation in response to many different pathogens.”

According to paleogeneticist Maria Avila Arcos, the study still has its limitations by only being carried out on a narrow population. The plague also affected parts of Asia and North Africa.

“There might be way more cellular mechanisms people used to cope with this devastating outbreak, but we’re just seeing the mechanisms shared across the English and Danish.”